徐洪

徐洪，男，汉族，1973年3月出生，现为南昌大学生物医学创新研究院教授，主要研究方向为神经发育和神经疾病。 ADFASDFAF23RQ23R

电子邮件：hongxucpu@hotmail.com；xuhnqz@gmail.com。 ADFASDFAF23RQ23R

2003年12月获得中国科学院上海生物化学和细胞生物学研究所生物化学和分子生物学专业博士学位。

2004年7月至2010年12月，美国宾夕法尼亚大学医学院神经科学系，博士后、助理研究员，研究大脑发育过程中神经回路的建立。 ADSFAEQWER353423413434

美国神经科学学会会员；中国神经科学学会会员。 ADSFAEQWER353423413434

神经环路发育与疾病，目前集中于发育相关神经精神疾病如孤独症，从分子、细胞和神经环路水平上解析其致病机制，为神经发育疾病的诊断和防治提供实验依据。

1. Zhu J, Wang H, Chen YR, Yan LY, Han YY, Liu LY, Cao Y, Liu ZZ, Xu HA. The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neurosci Bull. 2020 Sep;36(9):1023-1034.
2. Long X, Wang S, Luo Z, Zhang X, Xu HA. Comparison of three administration modes of establishing a zebrafish seizure model induced by NMDA. World Journal of Psychiatry. 2020 July 19; 10(7): 150-161.
3. Ying Chen, Hantsing Wang, Fang Wang, Chen Chen, Peng Zhang, Dandan Song, Tao Luo, Hong Xu, Xuhui Zeng. Sperm motility modulated by Trpv1 regulates zebrafish fertilization. Theriogenology. 2020 Jul 15;151:41-51.
4. Liu ZZ, Guo J, Lu Y, Liu W, Fu X, Yao T, Zhou Y, Xu HA. Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome. Int J Exp Pathol. 2019 Aug;100(4):234-243.
5. Luo ZW, Wang HT, Wang N, Sheng WW, Jin M, Lu Y, Bai YJ, Zou SQ, Pang YL, Xu HA, Zhang X. Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA. Int J Ophthalmol. 2019 Aug 18; 12 (8):1250-1261.
6. Zhu L, Chen L, Yan L, Perkins BD, Li S, Li B, Xu HA, Li XJ. Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function. Front Cell Neurosci. 2019 Mar 21;13:81.
7. Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong Xu. CRMP2 and CRMP4 are differentially required for axon guidance and growth in zebrafish retinal neurons. Neural Plasticity. 2018 Jun 21; 2018:8791304.
8. Zhi-Zhi Liu, Zi-Long Wang, Tae-Ik Choi, Wen-Ting Huang, Han-Tsing Wang, Ying-Ying Han, Lou-Yin Zhu, Hyun-Taek Kim, Jung-Hwa Choi, Jin-Soo Lee, Hyung-Goo Kim, Jian Zhao, Yue Chen, Zhuo Lu, Xiao-Li Tian, Bing-Xing Pan, Bao-Ming Li, Cheol-Hee Kim, Hong Xu. Chd7 is critical for early T-cell development and thymus organogenesis in zebrafish. Am J Pathol. 2018 Apr;188(4):1043-1058.
9. Weiwei Sheng, Ye Lu, Feng Mei, Ning Wang, Zhi-Zhi Liu, Ying-Ying Han, Han-Tsing Wang, Suqi Zou, Hong Xu, Xu Zhang. Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4542-4551.
10. Dell AL, Fried-Cassorla E, Xu H, Raper JA. cAMP-Induced Expression of Neuropilin1 Promotes Retinal Axon Crossing in the Zebrafish Optic Chiasm. J Neurosci. 2013 33(27):11076-88. (Highlighted as This Week in The Journal (TWIJ) article).

• 国家自然科学基金地区项目，孤独症基因CHD8在肠神经系统发育微环境中的作用和机制，批准号82260279，起止时间2023.1-2026.12。
• 江西省科技厅，江西省主要学科学术和技术带头人培养计划领军人才，批准号20213BCJ22057，起止时间2022.1-2024.12。
• 国家自然科学基金地区项目，孤独症高风险基因chd8在肠-免疫-脑中的作用和机制，批准号31960169，起止时间2020.1-2023.12。
• 江西省自然科学基金重点项目，表观遗传因子CHD8调节肠发育的分子细胞机制及从肠到脑的途径初探，批准号20202ACB206002，起止时间2020.1-2022.12。
• 国家自然科学基金地区项目，自闭症高风险基因Chd8在神经发生中的时序性调控作用和机制研究，批准号81760216，起止时间2018.1-2021.12。
• 江西省科技厅，江西省青年科学家（杰出青年），批准号20122BCB23007，起止时间2013.01-2015.12。
• 国家自然科学基金地区项目，Sema3E在CHARGE综合症中的作用及机制研究，批准号81160144，起止时间2012.01-2015.12。
• 国家自然科学基金面上项目，CRMP蛋白家族在中枢神经轴突生长和导向中的作用及机制研究，批准号31171044，起止时间2012.01-2015.12。

• 2010年4月12-17，中国苏州，the 1st Francis Crick Neuroscience Symposium. Presentation: The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing.
• 2008年9月10-14，Cold Spring Harbor, New York, USA, the 6th meeting on Axon guidance, Synaptogenesis & Neural Plasticity. Poster: Ca2+/Calmodulin-activated adenylate cyclases help modulate the effectiveness of midline repellents on retinal axons in the zebrafish embryo.
• 2003年10月15-17，中国武汉，第三届中国RNA学会年会暨第一届国际RNA培训班。大会报告，题目：Orientin特异性切割核糖体28S RNA C4453-A4454磷酸二酯键导致核糖体失活。

• Zhu J, Wang H, Chen YR, et al. The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neurosci Bull. 2020;36(9):1023-1034.
• Long X, Wang S, Luo Z, et al. Comparison of three administration modes of establishing a zebrafish seizure model induced by NMDA. World J Psychiatry. 2020;10(7):150-161.
• Chen Y, Wang H, Wang F, et al. Sperm motility modulated by Trpv1 regulates zebrafish fertilization. Theriogenology. 2020;151:41-51.
• Liu ZZ, Guo J, Lu Y, et al. Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome. Int J Exp Pathol. 2019;100(4):234-243.
• Luo ZW, Wang HT, Wang N, et al. Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA. Int J Ophthalmol. 2019;12(8):1250-1261.
• Zhu L, Chen L, Yan L, et al. Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function. Front Cell Neurosci. 2019;13:81.
• Liu ZZ, Zhu J, Wang CL, et al. CRMP2 and CRMP4 are differentially required for axon guidance and growth in zebrafish retinal neurons. Neural Plast. 2018;2018:8791304.
• Liu ZZ, Wang ZL, Choi TI, et al. Chd7 is critical for early T-cell development and thymus organogenesis in zebrafish. Am J Pathol. 2018;188(4):1043-1058.
• Sheng W, Lu Y, Mei F, et al. Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Invest Ophthalmol Vis Sci. 2018;59(11):4542-4551.
• Dell AL, Fried-Cassorla E, Xu H, Raper JA. cAMP-Induced Expression of Neuropilin1 Promotes Retinal Axon Crossing in the Zebrafish Optic Chiasm. J Neurosci. 2013;33(27):11076-11088.
• Zheng Z, Zhu T, Qu Y, et al. The emerging roles of the CHD8 gene in neurodevelopmental disorders. Front Mol Neurosci. 2020;13:597699.
• Feng Z, Zhou J, Xu Y, et al. Autism spectrum disorder risk gene CHD8 regulates gastrointestinal development and function. Cell Mol Gastroenterol Hepatol. 2021;12(4):1297-1317.
• O'Roak BJ, Vives L, Girirajan S, et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature. 2012;485(7397):246-250.
• Krumm N, Turner TN, Baker C, et al. Excess of rare, inherited truncating mutations in autism. Nat Genet. 2015;47(6):582-588.