李波

西湖大学，教授

Bo Li（李波）, He got his Ph.D. in the University of British Columbia in 2003 and finished his Postdoc in Roberto Malinow’s group in Cold Spring Harbor Laboratory. His research focuses on the neural circuits underlying cognitive function and dysfunction as they relate to anxiety, depression, schizophrenia and autism etc. He and his team have done a lot of ingenious studies, which were published in Nature, Nature Neuroscience, Neuron etc.

 
Research Focus

Understanding the link between neural circuits and behavior has been the focus of research in Li’s lab. The team is particularly interested in studying the synaptic and circuit mechanisms underlying reward processing, attention, and learning and memory; as well as synaptic and circuit dysfunctions responsible for maladaptive behaviors that are related to major mental disorders. This group integrates in vitro and in vivo electrophysiology, imaging, molecular, genetic, optogenetic, and chemogenetic techniques to probe and manipulate the function of specific neural circuits – with a focus on the fear and reward circuits – in the rodent brain, and to determine how these circuits participate in adaptive or maladaptive behavioral responses in various tasks.

 
Publications 

[1] Stephenson-Jones M, Yu K, Ahrens S, Tucciarone JM, van Huijstee AN, Mejia LA, Penzo MA, Tai LH, Wilbrecht L, Li B. (2016) A basal ganglia circuit for evaluating action outcomes. Nature. 2016 Sep 21. doi: 10.1038/nature19845.

[2] Yu, K., Garcia da Silva, P., Albeanu, D. F., Li, B. (2016) Central Amygdala Somatostatin Neurons Gate Passive and Active Defensive Behaviors.J Neurosci, 36 (24):6488-6496.

[3] Do Monte, F. H., Quirk, G. J., Li, B., Penzo, M. A. (2016) Retrieving fear memories, as time goes by. Mol Psychiatry, 21(8):1027-1036.

[4] Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F.,Palmiter, R. D., He, M., Huang, Z. J., Li, B. (2015) The paraventricular thalamus controls a central amygdala fear circuit. Nature, 519 (7544):455-459.

 [5] Ahrens, S., Jaramillo, S., Yu, K., Ghosh, S., Hwang, G., Paik, R., Lai, C., He, M., Huang, Z. J., Li, B.(2015) ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nature Neuroscience, 18:104-111

[6] Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., Li, B. (2013) Experience-dependent modification of a central amygdala fear circuit. Nature Neuroscience, 16 (3):332-339.

[7] Li, B., Piriz, J., Mirrione, M., Chung, C. H., Proulx, C. D., Schulz, D., Henn, F. A., Malinow, R. (2011)Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature, 470 (7335):535-U125.

[8] Li, B., Woo, R. S., Mei, L., Malinow, R. (2007) The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity. Neuron, 54 (4):583-597.

[9] Li, B., Chen, N., Luo, T., Otsu, Y., Murphy, T. H., Raymond, L. A. (2002) Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature Neuroscience, 5 (9):833-834.